RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-210
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
EDU assay; Dual-luciferase reporter assay etc.
Target
E2f3
Pathway
NA
PubMed ID
Title
MiR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia
Year
2012
Function
"Transcriptional induction of miR-210 in HPASMC is hypoxia-inducible factor-1a dependent. Inhibition of miR-210 in HPASMC caused a significant decrease in cell number due to increased apoptosis. MiR-210 mediates its antiapoptotic effects via the regulation of transcription factor E2F3, a direct target of miR-210."